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Food Function

Impact of dietary supplementation with olive and thyme phenols on alpha-tocopherol concentration in the muscle and liver of adult Wistar rats

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* Corresponding authors

Food Technology Department, UTPV-XaRTA, Agrotecnio Research Center, Escola Tècnica Superior d'Enginyeria Agrària, University of Lleida, Avda. Alcalde Rovira Roure 191, 25198 Lleida, Spain motilva@tecal.udl.es +34 973 702596 +34 973 702817

Estudis de Ciències de la Salut, Universitat Oberta de Catalunya, Barcelona, Spain

A preliminary study to evaluate the effect of dietary supplementation with olive phenols (oleuropein, hydroxytyrosol and secoiridoids), thyme phenols and a combination of these (5 mg per kg rat weight per day) on the α-tocopherol concentrations in the muscle and liver of healthy adult Wistar rats over 21 days was conducted. In addition, the excretion of α-tocopherol through the faeces was examined. The results demonstrated that the diet supplemented with some phenolic compounds of olive and thyme increased α-tocopherol ( < 0.05) in the liver of female rats, although the α-tocopherol content in the diet of all groups was identical. In addition, a synergic effect between the olive phenols and thyme was observed. Therefore, our study indicates a protective effect of olive and thyme phenols supplemented in the diet on α-tocopherol, resulting in a higher concentration of endogenous α-tocopherol in the rat liver.

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Publication details

The article was received on 02 Oct 2017, accepted on 20 Jan 2018 and first published on 22 Jan 2018

Article type: Paper
DOI: 10.1039/C7FO01533J
Citation: , 2018, 9 , 1433-1443
Food Funct.

The injection is given into a muscle, usually in the buttock, or into the thigh or tummy (abdomen). It should not be given during pregnancy. It is therefore important to be sure you are not pregnant when you have your first injection. However, if you were already pregnant without knowing, there is no evidence that it does the baby or the pregnancy any harm.

Sayana Press® has been designed so that you can give it to yourself. This may be useful if you have trouble getting to your surgery or clinic. Your doctor or nurse can teach you how to do this safely.

The doctor or nurse will tell you which type of injection you have and how long it is until the next injection. It can be given up to two weeks early. This may be convenient if, for example, you are due to be on a holiday when your next injection is due.

Note : don't forget, you will lose protection against pregnancy if you are late in having the next injection.

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Further reading and references

; Faculty of Sexual and Reproductive Healthcare (December 2014)

; NICE Clinical Guideline (September 2014)

; NICE CKS, December 2017 (UK access only)

; Faculty of Sexual and Reproductive Healthcare, 2016

; Faculty of Sexual Reproductive Healthcare (September 2015)

; Progestin-only contraceptives: effects on weight. Cochrane Database Syst Rev. 2016 Aug 28(8):CD008815. doi: 10.1002/14651858.CD008815.pub4.

; Contraceptive failure in the United States, Contraception, 2011

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We’re valuable assets precisely because we’ve had to learn coping mechanisms.

By Jenny Cooper

Photo illustration by Slate. Photo by George Marks/Getty Images.

Better Life Lab is a partnership of Slate and New America .

I rarely talk about my clinical anxiety at my job in advertising sales at Google, but when I do, I always add the quick caveat that “It doesn’t affect my work.” I attempt to breezily explain that my anxiety is around relationships and social activities, not work , for fear that my co-workers will think I’m not able to handle workloads or stressful assignments the same way they can.

I’m not alone. According to the Anxiety and Depression Association of America, only one-fourth of those with an anxiety disorder have told their employers about their diagnosis. Thirty-eight percent of those who hadn’t worried that “their boss would interpret it as lack of interest or unwillingness to do the activity” while 34 percent of them worried it would affect their promotion opportunities.

But recently, I’ve come to realize my anxiety isn’t holding me back at work but actually making me a better employee.

According to Nanci Pradas, who has 30 years of experience as a therapist, “There’s evidence to show that people who overcome thought distortions and automatic thoughts (symptoms of anxiety) can think more quickly, get promotions more frequently, and be more assertive.” And explaining how just might help break down the stigma about anxious workers.

My journey with anxiety probably started in college but hit a breaking point soon after, when I started a new job and broke up with my long-term boyfriend. I started seeing a therapist who specializes in cognitive behavioral therapy, or CBT, a form of psychological treatment that focuses on addressing mental health problems through active behavior change. My anxiety was exhausting, all-encompassing, and painful to work through. But the truth is after four years of therapy and targeted medication, I have learned valuable lessons that I wouldn’t have if I didn’t have anxiety.

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I often describe my anxiety as going down a big mind spiral, where unfounded thoughts lead to even more unlikely imagined scenarios, such as “My boyfriend and I got in a fight. Now he’s definitely going to break up with me, and I’ll be alone forever. I better start researching egg freezing,” which start to feel not just possible but inevitable.

This also happens in the workplace: I’ve seen people translate one odd look in a meeting to the assumption that a client is going to pull all of its spend. This creates unnecessary stress and work when it most often isn’t even needed, work often described by the workplace lingo of “spinning your wheels.”

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